Fear-Related Reasons for Avoiding Sexual Intercourse in Early Pregnancy: A Cross-Sectional Study.

INTRODUCTION: Several studies have reported women's worry that sexual intercourse may harm the course of pregnancy. This worry might lead to avoidance of sexual intercourse during pregnancy. AIM: To assess if fears about harming the pregnancy are associated with avoidance of sexual intercourse during pregnancy. METHODS: A cross-sectional study was conducted on 250 Vietnamese pregnant women in the first or second trimester who visited our hospital for antenatal care. We explored 5 types of fears including miscarriage/preterm labor, premature rupture of membranes, bleeding, infection, and injury to the fetus. Fears were measured by modified questions from the Reasons For Not Engaging in Sexual Activity During Pregnancy questionnaire. Using the total fear score, pregnant women were categorized into having low, moderate, and high fear. MAIN OUTCOME MEASURE: Not having sexual intercourse during the past 4 weeks. RESULTS: 72 (28.8%) pregnant women had no sexual intercourse for the past 4 weeks. All types of fear were considered important among pregnant women; the more important fears were infection and injury to the fetus. In multivariable regression analysis, the prevalence of not having sexual intercourse was higher in both women who had moderate (adjusted prevalence ratio = 2.84, 95% CI 1.42-5.67) and high fear (adjusted prevalence ratio = 4.39, 95% CI 2.28-8.44). CONCLUSION: Avoidance of sexual intercourse was common among Vietnamese pregnant women and was associated with the fears about harming the pregnancy. This can be a target in the health education programs for pregnancy couples. Thanh C. Phan, Long B. Hoang, Thanh K. Tran, et al. Fear-Related Reasons for Avoiding Sexual Intercourse in Early Pregnancy: A Cross-Sectional Study. Sex Med 2021;9:100430.

Bimetallic Ag-Zn-BTC/GO composite as highly efficient photocatalyst in the photocatalytic degradation of reactive yellow 145 dye in water.

Agx-Zn100-x-BTC/GO composites (BTC: benzene-1,3,5-tricarboxylic, GO: graphene oxide) with different Ag/Zn molar ratios were synthesized using microwave-assisted hydrothermal treatment. The Agx-Zn100-x-BTC/GO exhibited excellent photocatalytic performance in the reactive yellow 145 dye (RY-145) degradation under irradiation of visible light with nearly 100% of RY-145 removal after 35 min, as compared to Zn-BTC/GO and Ag-BTC/GO. Reactive oxygen species scavenging assays have shown that the holes (h+) and superoxide radical anion (O2-•) play a primary role in RY-145 degradation. Based on the band structure of materials, the Z-scheme photocatalytic mechanism was suggested. The effect of catalyst dosage, pH and dye concentration on the efficiency of photocatalytic activity of bimetallic Ag50-Zn50-BTC/GO was also investigated. The improvement in photocatalytic activity of bimetallic Ag50-Zn50-BTC/GO could be given by the synergism of (i) absorption of visible light confirmed by UV-Vis diffuse reflectance spectra; (ii) the increased lifetime as evidenced by photoluminescence spectra and transient photocurrent response; (iii) the increased oxygen vacancy defects as confirmed by X-ray photoelectron spectroscopy results. The degradation pathway of RY-145 dye was also predicted based on liquid chromatography-mass spectrometer analysis. The removed chemical oxygen demand, biological oxygen demand, total organic carbon outcomes indicated the high mineralization ability for RY-145 degradation over Ag50-Zn50-BTC/GO.

A functional polymorphism in the NKG2D gene modulates NK-cell cytotoxicity and is associated with susceptibility to Human Papilloma Virus-related cancers.

Human papillomavirus (HPV) is the most common sexually transmitted agent worldwide and is etiologically linked to several cancers, including cervical and genital cancers. NKG2D, an activating receptor expressed by NK cells, plays an important role in cancer immune-surveillance. We analyzed the impact of a NKG2D gene variant, rs1049174, on the incidence of HPV-related cancers in Vietnamese patients and utilized various molecular approaches to elucidate the mechanisms of NKG2D receptor regulation by rs1049174. In a group of 123 patients with HPV+ anogenital cancers, the low cytotoxicity allele LNK was significantly associated with increased cancer susceptibility (p = 0.016). Similar results were also observed in a group of 153 women with cervical cancer (p = 0.05). In functional studies, NK cells from individuals with LNK genotype showed a lower NKG2D expression and displayed less efficient NKG2D-mediated functions than NK cells with HNK genotype. Notably, the rs1049174 variant occurs within a targeting site for miR-1245, a negative regulator of NKG2D expression. Compared with the higher cytotoxicity allele HNK, the LNK allele was more efficiently targeted by miR-1245 and thus determined lower NKG2D expression in NK cells with the LNK genotype. The NKG2D variants may influence cancer immunosurveillance and thus determine susceptibility to various malignancies, including HPV-induced cancers.